Vitamin D-3 High Dose (D3-5000)

Recently, Lappe et al. reported the first population-based, double-blind, randomized, placebo-controlled, interventional trial of cholecalciferol (vitamin D) with non-skin cancer prevention as a principal secondary end point [1]. They found that 1100 IU of vitamin D and 1500 mg of calcium per day administered to 403 Nebraska women over 4 years dramatically reduced the relative risk (0.232) for incident cancers compared with 206 placebo controls (p < 0.005). Furthermore, baseline and treatment-induced serum 25-hydroxy-vitamin D (25[OH]D) levels were strong and independent predictors of cancer risk. Besides cancer, vitamin D deficiency is associated with cardiovascular disease, hypertension, stroke, diabetes, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, periodontal disease, macular degeneration, mental illness, propensity to fall and chronic pain.

The Mayo Clinic* lists strong, or good clinical evidence for the use of Vitamin D-3 supplements in the following conditions:
Rickets, psoriasis, osteomalacia, hypoparathyroidism, hypercalcemia due to hypoparathyroidism, hypophosphatemia, Fanconi syndrome, osteoporosis, renal osteodystrophy, muscle weakness, muscle pain.
The Mayo Clinic* lists the following conditions where more study is needed/under investigation: breast cancer prevention, colorectal cancer, cancer prevention (some other cancers), corticosteroids-induced osteoporosis, Type 2 diabetes ( In recent studies, adults given vitamin D supplementation were shown to improve insulin sensitivity.), fall prevention, hepatic osteodystrophy, high blood pressure, hypertriglyceridemia, immunomodulation, total mortality reduction, multiple sclerosis, Myelodysplastic syndrome, osteogenesis imperfecta, osteoporosis in cystic fibrosis, proximal myopathy, seasonal affective disorder (SAD), senile warts, skin pigmentation disorders, tooth retention, Vit D deficiency in breast-feeding mothers, post menopausal weight gain.
The Mayo Clinic* list the following conditions as strong scientific evidence against use in: increasing muscle strength, prostate cancer.
The Mayo Clinic* cites use based on tradition, or theory in following conditions: Actinic keratosis, Alzheimer's disease associated hip fractures, ankylosing spondylitis, autoimmune disorders, Graves disease, hyperparathyroidism in renal dialysis, hypocalcemia, hypocalcemic tetany, kidney transplant-related bone loss, metabolic disorders (metabolic syndrome), nervous system disorders (hemichorea), osteitis fibrosa. in dialysis, rheumatoid arthritis, scleroderma, squamous cell carcinoma, systemic lupus erythematosus, vaginal disorders (atrophy), vitiligo.*

SUPPLEMENT FACTS
Each capsule contains:

Vitamin D-3 (Cholecalciferol from fish liver oil) 5,000 IU
Other ingredients: maltodextrin, gelatin (100% preservative-free), plant cellulose, magnesium trisilicate, magnesium stearate, and natural silica.

SIZE: 100 capsule bottle

DOSAGE: one capsule per day